A Discussion on the Relationship Between Gender Identity And Prenatal Exposure to Diethylstilbestrol (DES) in 46XY Individuals 

   Table 3

 

 

 

 

Now it's time to look at gender identity issues which some people with Intersexed conditions are known to have. As a baseline lets start with people (genetic 46XY) who have CAIS.


 

From - Complete Androgen Insensitivity Syndrome: Long-Term Medical, Surgical, and Psychosexual Outcome, Amy B. Wisniewski, Claude J. Migeon, Heino F. L. Meyer-Bahlburg, John P. Gearhart, Gary D. Berkovitz, Terry R. Brown and John Money, May 2000:

"Self-perceived femininity and masculinity. Women with CAIS overwhelmingly reported a high degree of femininity along with a low degree of masculinity throughout development."

"Satisfaction with sex of rearing. CAIS women unanimously reported satisfaction with being a woman (100%). Two participants (18%) questioned their physical status as women, but none reported a desire to change sex to that of a man."


 

From - Psychological outcomes and gender-related development in complete androgen insensitivity syndrome. M Hines, SF Ahmed, and IA Hughes (Abstract):

"Women recruited through the database versus the support group did not differ systematically, and there were no statistically significant differences between the 22 women with CAIS and the matched controls for any psychological outcome. These findings argue against the need for two X chromosomes or ovaries to determine feminine-typical psychological development in humans and reinforce the important role of the androgen receptor in influencing masculine-typical psychological development. They also suggest that psychological outcomes in women with CAIS are similar to those in other women."


 

Please note that the above two reports indicate that all the participants in the study, although genetically 46XY have feminine gender identities. Remember the studies done by Dr. Reimer shown on the previous page which report attempts at trying to raise boys as girls who had normal prenatal hormone exposure to testosterone and the subsequent failures. Now lets look at some psychological reports which include people who have PAIS, Partial gonadal dysgenesis and other Intersexed conditions.


 

This study done in 2002 on the psychosexual characteristics of a number of 46XY intersexed people including PAIS and partial gonadal dysgenesis indicates the following 176):

"Results.Thirty-nine (72%) of 54 eligible patients participated. The causes underlying genital ambiguity of participants included partial androgen insensitivity syndrome (n = 14; 5 men and 9 women), partial gonadal dysgenesis (n = 11; 7 men and 4 women), and other intersex conditions."

Participants Currently Living as Men Physical Appearance at Birth:
"Classification of the appearance of the external genitalia ranged from Quigley grade 2 to 4 (mean: 3.4)."

Participants Currently Living as Women Physical Appearance at Birth:
"Classification of the appearance of the external genitalia ranged from Quigley grade 3 to 4 (mean: 3.6)."

Comparison of Men’s and Women’s Responses Satisfaction With Parent/Physician-Assigned Gender:
"Sixteen participants (76%) were mainly satisfied with their male sex of rearing established by physicians and parents. Five participants (24%) reported dissatisfaction with their male sex of rearing, one of whom preferred to think of himself as intersex and one reassigned her gender to that of a woman in early adulthood. Fourteen participants (78%) were mainly satisfied with their physician/parent-established female sex of rearing. Four participants (22%) reported dissatisfaction with their female sex of rearing."

"It is possible that those who refused to participate were particularly dissatisfied with their sex assignment established by parents and physicians and their medical or surgical treatment; in addition, some preferred not to discuss their intersex condition. Finally, establishing a cause underlying the genital ambiguity of participants in the present study also proved difficult, particularly in cases of PAIS."
Note the percentages of individuals dissatisfied with their sex of rearing.


 

Another study indicating some intersexual children switch gender roles later on in life: Psychological consequences 188): "Sex assignment of children born with ambiguous genitalia is a difficult and responsible decision based on limited empirical evidence regarding future development of gender identity/role, sexual orientation, and sexual functioning. The limited follow-up studies indicate that this is a reasonable policy, although a limited number of subjects will experience gender dysphoria later in life and will cross over to the other sex."


 

And another 192)  "Despite the sex assignment, genital organ correction soon after birth, psychological counseling of parents and intensive psychotherapy of the children, general psychopathology developed equally in all 4 groups (39% of total group). Although 87% of the girls with a physical intersex condition developed in line with the assigned sex, 13% developed a gender identity disorder though only 1 girl (2%) failed to accept the assigned sex. Gender identity disorder and deviant gender role were in evidence only in girls with CAH and girls of the ambiguous group. Biological and social factors seem responsible for the development of gender identity disorder, such as pre- and postnatal hormonal influences on the brain enabling deviant gender role behavior to develop, and an inability on the part of parents to accept the sex assignment."


 

The Androgen Insensitivity Syndrome Support Group (AISSG)   web site also describes the seven grades of AIS and provides support access for those with mild PAIS, raised as males but who have a feminine gender identity.


 

If we look at the physical similarities between DES exposure, AIS and Gonadal dysgenesis and then we look at the gender identity problems some of these people face why would we not expect similar gender identity problems to occur with genetic males exposed to DES in utero? 

 

 

 

 

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