A Discussion on the Relationship Between Gender Identity And Prenatal Exposure to Diethylstilbestrol (DES) in 46XY Individuals 

   Timelines

 

 

 

References: Diethylstilbestrol (DES) Literature Referencing Gender Identity, Transsexualism, or Disturbances in Sexual Differentiation in Exposed Males
July 2004 Update
by Scott Kerlin, Ph.D., DES Sons International Network

Online: http://health.groups.yahoo.com/group/des-sons

1950's

Kaplan, N.M. (1959) Male pseudohermaphrodism: Report of a case, with observations on pathogenesis. New England Journal of Medicine 261: 641.


1970's

Yalom, I.D., R. Green, and N. Fisk. (1973). Prenatal exposure to female hormones: Effect on psychosexual development in boys. Archives of General Psychiatry (April) 28: 554.

Ober, W.B. (1976). Stilbestrol: A pathologist’s view. Pathology Annual 11: 227.

Seyler, L.E., E. Canalis, S. Spare, and S. Reichlin (1978). Abnormal gonadotropin secretory responses to LRH in transsexual women after diethylstilbestrol priming. Journal of Clinical Endocrinology and
Metabolism 47: 176.

Green, R. (1978). Sex-dimorphic behaviour development in the human: Prenatal hormone administration and postnatal socialization. Ciba Foundation Symposium (March 14) 62: 59.

Meyer-Bahlburg, H.F.L. (1978). Behavioral effects of estrogen treatment in human males. Pediatrics
(December) 62 (6): 1171.

1980's

Kester, P., R. Green, S. Finch, and K. Williams, (1980). Prenatal ‘female hormone’ administration and psychosexual development in human males. Psychoneuroendocrinology, 5, 269-285.

Ehrhardt, A., and H.F.L. Meyer-Bahlburg. (1981). Effects of prenatal sex hormones on gender-related behavior. Science (March 20) 211: 1312.
Online Abstract:
http://highwire.stanford.edu/cgi/medline/pmid;7209510

Hines, M. (1982). Prenatal gonadal hormones and sex differences in human behaviour. Psychological Bulletin, 92, 56-80.

Vessey, M.P., D.V. Fairweather, B. Norman-Smith, and J. Buckley. (1983). A randomized double-blind controlled trial of the value of stilboestrol therapy in pregnancy: long-term follow-up of mothers and their offspring. British Journal of Obstetrics and Gynaecology 90(11): 1007.

Reinisch, J.M., and S. Sanders (1984). Prenatal gonadal steroidal influences on gender-related behavior. Progress in Brain Research 61: 407.

Kwan, M., J. Vanmaasdam, and J.M. Davidson. (1985). Effects of estrogen treatment on male-to-female transsexuals: Experimental and clinical observations. Archives of Sexual Behavior (February) 14 (1):29.
Abstract:
http://highwire.stanford.edu/cgi/medline/pmid;2983641

McEwen, B.S. (1987). Steroid hormones and brain development: Some guidelines for understanding actions of pseudohormones and other toxic agents. Environmental Health Perspectives (October) 74: 177.
Online full-text (pdf):
http://ehp.niehs.nih.gov/members/1987/074/74020.PDF

Gill, W.B. (1988). Effects on human males of in-utero exposure to exogenous sex hormones. In T. Mori and H.Nagasawa (eds.), Toxicity of Hormones in Perinatal
Life (Boca Raton: CRC Press), 161.

Asscheman, H., L.J.G. Gooren, and P.L.E. Eklund. (1989). Mortality and morbidity in transsexual patients with cross-gender hormone treatment. Metabolism 38: 869.
Abstract:
http://highwire.stanford.edu/cgi/medline/pmid;2528051

1990's

Reinisch, J. M., M. Ziemba-Davis, and S.A. Sanders (1991). Hormonal contributions to sexually dimorphic behavioral development in humans. Psychoneuroendocrinology 16: 213.
Abstract:
http://highwire.stanford.edu/cgi/medline/pmid;1961841

Giusti, R.M., K. Iwamoto, and E.E. Hatch. (1995).Diethylstilbestrol revisited: A review of the long-term health effects. Annals of Internal Medicine (May 15) 122 (10): 778.
Abstract:
http://www.annals.org/cgi/content/abstract/122/10/778

Collaer, M.L., and M. Hines (1995). Human behavioral sex differences: A role for gonadal hormones during early development? Psychological Bulletin 118: 55.

Bem, D.J. (1996). Exotic becomes erotic: A developmental theory of sexual orientation. Psychological Review 103: 320.

Dictionary of Organic Compounds, 6th Edition (1996). Buckingham, J., and F. Macdonald. (eds.): Diethylstilbestrol entry (Volume 3, 2175).

Toppari, J., and N.E. Skakkebaek. (1998). Sexual differentiation and environmental endocrine disrupters. Bailliere’s Clinical Endocrinology and Metabolism (April) 12 (1): 143.
Abstract:
http://highwire.stanford.edu/cgi/medline/pmid;9890066

Dessens, A.B., Cohen-Kettenis, P., Mellenbergh, G.J., v.d. Poll, N., Koppe, J.G., and Boer, K. (1999). Prenatal exposure to anticonvulsants and psychosexual development. Archives of Sexual Behavior 28: 31.

Wilson, J.D. (1999). The role of androgens in male gender role behavior. Endocrine Reviews 20: 726.
Abstract:
http://edrv.endojournals.org/cgi/content/abstract/20/5/726


2000's

Berkson, D.L. (2000). Hormone Deception. New York: Contemporary Books.

Verdoux, H. (2000). Does prenatal exposure to diethylstilbestrol (DES) have psychiatric consequences? Annales Medico-Psychologiques 158: 105.

Michel, A., C. Mormont, and J.J. Legros. (2001). A psycho-endocrinological overview of transsexualism. European Journal of Endocrinology 145: 365.
Online:
http://www.eje.org/eje/145/eje1450365.htm

Sultan, C., P. Balaguer, B. Terouanne, V. Georget, F. Paris, C. Jeandel, S. Lumbroso, and J. Nicolas. (2001). Environmental xenoestrogens, antiandrogens and disorders of male sexual differentiation. Molecular and Cellular Endocrinology 178: 99.
Abstract:
http://highwire.stanford.edu/cgi/medline/pmid;11403899

Alexander, G., and B.S. Peterson (2001). Sex steroids and human behavior: Implications for developmental psychopathology. CNS Spectrums 6: 75.

Sharpe, R.M. (2001). Hormones and testis development and the possible adverse effects of environmental chemicals. Toxicology Letters 120: 221.

National Toxicology Program, National Institutes of Health. (2001). NTP Chemical Repository: Diethylstilbestrol. (last accessed 2003 on NTP website,
http://ntp-server.niehs.nih.gov)

Friedman, R.C., and Downey, J.I. (2002). Sexual orientation and psychoanalysis: Sexual science and clinical practice. New York: Columbia University Press.

Swaab, D.F., W.C. Chun, F.P. Kruijver, M.A. Hofman, and T.A. Ishunina. (2002). Sexual differentiation of the human hypothalamus. Advances in Experimental Medicine and Biology511: 75.
Abstract:
http://highwire.stanford.edu/cgi/medline/pmid;12575757

Toppari, J., and N.E. Skakkebaek. (2002). Environmental endocrine disrupters and disorders of sexual differentiation. Seminars in Reproductive Medicine 20: 305.
Abstract:
http://highwire.stanford.edu/cgi/medline/pmid;12428210

Verdoux, H. (2002). Long-term psychiatric and behavioural consequences of prenatal exposure to psychoactive drugs. Therapie (March) 57(2): 181.
Abstract:
http://highwire.stanford.edu/cgi/medline/pmid;12185968

Kerlin, S., and D. Beyer. (2003). The DES Sons’ online discussion network. Transgender Tapestry #100.

Udry, R. (2003). Putting prenatal effects of sex-dimorphic behavior in perspective: An absolutely complete theory. Epidemiology 14 (2): 135.

Baron-Cohen, S. (2003). The Essential Difference: Men,
Women and the Extreme Male Brain. New York: Penguin.

Sayed, Y., and P. Taxel. (2003). The use of estrogen therapy in men. Current Opinion in Pharmacology (December) 3: 650.
Abstract:
http://highwire.stanford.edu/cgi/medline/pmid;14644018

Kula, K., J. Slowikowska-Hilczer. (2003). Consequences of disturbed sex-hormone action in the central nervous system: Behavioral, anatomical and functional changes. Neurol Neurochir Pol. 37 Suppl 3: 19.
Abstract:
http://highwire.stanford.edu/cgi/medline/pmid;14560698

Ohyama, K. (2004). Disturbances of sex differentiation caused by exogenous hormones. Nippon Rinsho 62: 379.

Arai, Y. (2004). Sex differentiation of central nervous system--brain of man and woman. Nippon Rinsho 62: 81.




DES Research Sources by Decade, Including Issues
Primarily Affecting DES Sons

By Scott Kerlin, Ph.D., DES Sons International Network
February 2004 (Version 2.0)

1930's
Dodds, E.C., L. Goldberg, W. Lawson, and R. Robinson. (1938). Oestrogenic activity of certain synthetic compounds. Nature (Feb. 5) Vol. 141: 247.

Selye, H. (1939). On the toxicity of oestrogens with special reference to diethylstilbestrol. Canadian Medical Association Journal (July), 48.

Shorr, E., F. Robinson, and G. N. Papanicolaou. (1939). A clinical study of the synthetic estrogen stilbestol. Journal of the American Medical Association (Dec. 23) 113 (26): 2312.

Buxton, C.L., and E.T. Engle. (1939). Effects of the therapeutic use of diethylstilbestrol. Journal of the American Medical Association (Dec. 23) 113 (26): 2318.

1940's
Atkinson, D.W. (1940). A review of experimental and clinical trials of stilbestrol. Endocrinology (August) 27(2): 161.

Greene, R.R., M.W. Burrill, and A.C. Ivy. (1940). Experimental intersexuality: The effects of estrogens on the antenatal sexual development of the rat. American Journal of Anatomy 67: 305.

Greene, R.R. (1944). Embryology of sexual structure and hermaphroditism. Journal of Clinical Endocrinology 4: 335.

Fitzsimons, M.P. (1945). Gynaecomastia in stilboestrol workers. British Journal of Industrial Medicine 1: 235.

Huggins, C. (1946). Prostatic carcinoma treated by orchiectomy: 5 year results. Journal of the American Medical Association 131: 576.
 
1950's
Dieckmann, W.J., M.E. Davis, L.M. Rynkiewicz, and R.E. Pottinger. (1953). Does the administration of diethylstilbestrol during pregnancy have therapeutic value? American Journal of Obstetrics and Gynecology (November) 66: 1062.

Ferguson, J.H. (1953). Effects of stilbestrol on pregnancy compared to the effect of a placebo. American Journal of Obstetrics and Gynecology 65: 592.

Bongiovani, A.M., A.M. DiGeorge, and M.M. Grumbach. (1959). Masculinization of the female infant associated with estrogenic therapy alone during gestation: Four cases. Journal of Clinical Endocrinology and Metabolism (August) 19: 1004.

Kaplan, N.M. (1959) Male pseudohermaphrodism: Report of a case, with observations on pathogenesis. New England Journal of Medicine 261: 641.
 
1960's
Cleveland, W.M., and G.C.H. Chang (1965). Male pseudohermaphroditism with female chromosomal constitution. Pediatrics (December) 36 (6): 892.
 
1970's
FDA Drug Bulletin (1971, November). Diethystilbestrol Contraindicated in Pregnancy.

Heinonen, O.P. (1973). Diethylstilbestrol in pregnancy: Frequency of exposure and usage patterns. Cancer (March) 31: 573.

Yalom, I.D., R. Green, and N. Fisk. (1973). Prenatal exposure to female hormones: Effect on psychosexual development in boys. Archives of General Psychiatry (April) 28: 554.

Lanier, A.P., K.L. Noller, D.G. Decker, L.R. Elveback, and L.T. Kurland. (1973). Cancer and stilbestrol: A follow-up of 1,719 persons exposed to estrogens in utero and born 1943-1959. Mayo Clinic Proceedings (November) 48: 793.

Kinlen, L.J., M.A. Badracco, J. Moffett, and M.P. Vessey. (1974). A survey of the use of oestrogens during pregnancy in the United Kingdom and of the genito-urinary cancer mortality and incidence rates in young people in England and Wales. The Journal of Obstetrics and Gynaecology of the British Commonwealth (November) 81: 849.

Hook, E.B. O.P, Heinonen, S. Shapiro, and D. Slone. (1974). Maternal exposure to oral contraceptives and other female sex hormones: Relation to birth defects in a prospectively ascertained cohort of 50,282 pregnancies. Teratology 9: A-21.

Noller, K.L., and C.R. Fish. (1974). Diethylstilbestrol usage: Its interesting past, important present, and questionable future. Medical Clinics of North America (July) 58 (4): 793.

Bibbo, M., A. Maysoon, I. Baccarini, W. Gill, M. Newton, KM. Sleeper, M. Sonek, and G.L. Wied. (1975). Follow-up study of male and female offspring of DES-treated mothers. The Journal of Reproductive Medicine (July) 15 (1): 29.

Gill, W.B. , G.F.B. Schumacher, and M. Bibbo. (1976). Structural and functional abnormalities in the sex organs of male offspring of mothers treated with diethylstilbestrol. Journal of Reproductive Medicine 16 (4): 147.

Hoefnagel, D. (1976). Prenatal diethylstilbestrol exposure and male hypogonadism. Lancet (January 17).

Ober, W.B. (1976). Stilbestrol: A pathologist’s view. Pathology Annual 11: 227.

Henderson, B.E., B. Benton, M. Cosgrove, J. Baptista, J. Aldrich, D. Townsend, W. Hart, and T. M. Mack. (1976). Urogenital tract abnormalities in sons of women treated with diethylstilbestrol. Pediatrics (October) 58 (4): 505.

Bibbo, M., W.B. Gill, F. Azizi, R. Blough, V.S. Fang, R.L. Rosenfield, G.F.B. Schumacher, K. Sleeper, M.G. Sonek, and G.L. Wied. (1977). Follow-up study of male and female offspring of DES-exposed mothers. Journal of Obstetrics and Gynecology (January) 49 (1): 1.

Cosgrove, MD., B. Benton, and B.E. Henderson. (1977). Male genitourinary abnormalities and maternal diethylstilbestrol. Journal of Urology (February) 117: 220.

Gill, W.B., Schumacher, G.F.B., and M. Bibbo. (1977). Pathological semen and anatomical abnormalities of the genital tract in human male subjects exposed to diethylstilbestrol in utero. Journal of Urology (April) 117: 477.

Schwartz, R.W., and N.B. Stewart. (1977). Psychological effects of diethylstilbestrol exposure. Journal of the American Medical Association 237: 252.

Herbst, A.L., R.E. Scully, S.J. Robboy, and W.R. Welch. (1978). Complications of prenatal therapy with diethylstilbestrol. Pediatrics (December) 62 (6): 1151.

Ehrhardt, A.A., and H.F. Meyer-Bahlburg. (1978). Psychosexual development: an examination of the role of prenatal hormones.  Ciba Foundation Symposium (March 14) 62: 41. 

Green, R. (1978). Sex-dimorphic behaviour development in the human: Prenatal hormone administration and postnatal socialization.  Ciba Foundation Symposium (March 14) 62: 59.

Mills, J.L., and A.M. Bongiovanni. (1978). Effect of prenatal estrogen exposure on male genitalia. Pediatrics (December) 62 (6): 1160.

Meyer-Bahlburg, H.F.L. (1978). Behavioral effects of estrogen treatment in human males. Pediatrics (December) 62 (6): 1171.

Gill, W.B., G.F.B. Schumacher, M. Bibbo, F.H. Straus, and H.W. Schoenberg. (1979). Association of diethylstilbestrol exposure in utero with cryptorchidism, testicular hypoplasia, and semen abnormalities. Journal of Urology, 122: 36.

Andonian, R.W., and R. Kessler. (1979). Transplacental exposure to diethylstilbestrol in men. Urology 13: 276.

Shapiro, S., and D. Slone. (1979). The effects of exogenous female hormones on the fetus.  Epidemiologic Reviews 1: 110.

1980's
Burke, L., RJ Apfel, S. Fisher, and J. Shaw. (1980). Observations on the psychological impact of diethylstilbestrol exposure and suggestions of management. Journal of Reproductive Medicine 24: 99.

Kester, P., R. Green, S. Finch, & K. Williams, (1980). Prenatal ‘female hormone’ administration and psychosexual development in human males. Psychoneuroendocrinology, 5, 269-285.

Ulfelder, H. (1980). The stilbestrol disorders in historical perspective. Cancer (June 15) 45 (12): 3008.

Ehrhardt, A., and H.F.L. Meyer-Bahlburg. (1981). Effects of prenatal sex hormones on gender-related behavior. Science (March 20) 211: 1312.

Beral, V., and L. Colwell. (1981). Randomized trial of high doses of stilboestrol and ethisterone therapy in pregnancy: Long-term follow-up of the children. Journal of Epidemiology and Community Health 35: 155.

Whitehead, E.D., and E. Leiter. (1981). Genital abnormalities and abnormal semen analyses in male patients exposed to diethylstilbestrol in utero. Journal of Urology 125: 47.

Stenchever, M.A., R.A. Williamson, J. Leonard, L.E. Karp, B. Ley, K. Shy, and D. Smith. (1981). Possible relationship between in utero diethylstilbestrol exposure and male fertility. American Journal of Obstetrics and Gynecology 140 (2): 186.

Stillman, R.J. (1982). In utero exposure to diethylstilbestrol: Adverse effects on the reproductive tract and reproductive performance in male and female offspring. American Journal of Obstetrics & Gynecology (April 1) 142 (7): 905.

Hines, M. (1982). Prenatal gonadal hormones and sex differences in human behaviour. Psychological Bulletin, 92, 56-80.

Koss, R.K., P. Garbeff, A. Paganini-Hill, and B.E. Henderson. (1983). Effect of in-utero exposure to diethylstilbestrol on age at onset of puberty and on postpubertal hormone levels in boys. Canadian Medical Association Journal (May 15) 128: 1197.

Vessey, M.P.,  D.V. Fairweather, B. Norman-Smith, and J. Buckley. (1983). A randomized double-blind controlled trial of the value of stilboestrol therapy in pregnancy: long-term follow-up of mothers and their offspring. British Journal of Obstetrics and Gynaecology (November) 90(11): 1007.

Hines, M., and C. Shipley. (1984). Prenatal exposure to diethylstilbestrol (DES) and the development of sexually dimorphic cognitive abilities and cerebral lateralization. Developmental Psychology 20:81.

Shy, K.K., M.A. Stenchever, L.E. Karp, R.E. Berger, R.A. Williamson, and J. Leonard. Genital tract examinations and zona-free hamster egg penetration tests from men exposed in utero to diethylstilbestrol. Fertility and Sterility (November) 42 (5): 772.

Leary, F.J., L.J. Resseguie, L.T. Kurland, P.C. O’Brien, R.F. Emslander, and K.L. Noller. (1984). Males exposed in utero to diethylstilbestrol. Journal of the American Medical Association (December 7) 252 (21): 2984.

Ehrhardt, A.A., H.F.L. Meyer-Bahlburg, L.R. Rosen, J.F. Feldman, N.P. Veridiano, I. Zimmerman, and B.S. McEwen. (1985). Sexual orientation after prenatal exposure to exogenous estrogen. Archives of Sexual Behavior, 14: 57.

Meyer-Bahlburg, H.F.L., A. Ehrhardt, J. Endicott, N.P. Veridiano, E.D. Whitehead, and F.H. Vann. (1985). Depression in adults with a history of prenatal DES exposure. Psychopharmacology Bulletin 21 (3): 686.

Kwan, M., J. Vanmaasdam, and J.M. Davidson. (1985). Effects of estrogen treatment on male-to-female transsexuals: Experimental and clinical observations. Archives of Sexual Behavior (February) 14 (1): 29.

Niculescu, A.M. (1985). Effeccts of in utero exposure to DES on male progeny. Journal of Obstetric,Gynecological and Neonatal Nursing 14 (6): 468.

Meyer-Bahlburg, H.F.L., and A. Ehrhardt. (1986). Prenatal diethylstilbestrol exposure: Behavioral consequences in humans. Monograms in Neural Science 12: 90.

Meyer-Bahlburg, H.F.L., and A. Ehrhardt. (1987). A prenatal-hormone hypothesis for depression in adults with a history of fetal DES exposure. In U. Halbriech (Ed.), Hormones and Depression (N.Y.: Raven Press), 325. 

Katz, D.L., F.R. Frankenburg, L.I. Benowitz, and J.M. Gilbert. (1987). Psychosis and prenatal exposure to diethylstilbestrol. Journal of Nervous and Mental Disease (May) 175 (3): 306.

McEwen, B.S. (1987). Steroid hormones and brain development: some guidelines for understanding actions of pseudohormones and other toxic agents.  Environmental Health Perspectives (October) 74: 177.

Gill, W.B. (1988). Effects on human males of in-utero exposure to exogenous sex hormones. In T. Mori and H. Nagasawa (eds.), Toxicity of Hormones in Perinatal Life (Boca Raton: CRC Press), 161.

Saunders, E.J. (1988). Physical and psychological problems associated with exposure to diethylstilbestrol (DES). Hospital and Community Psychiatry (January) 39 (1): 73.

Gershman, S.T., and P.D. Stolley. A case-control study of testicular cancer using Connecticut tumor registry data. (1988). International Journal of Epidemiology 17: 738.

Wortsman, J., A. Hamidinia, and S.J. Winters. (1989). Hypogonadism following long-term treatment with diethylstilbestrol. American Journal of the Medical Sciences (June) 297 (6): 365.

Williams, F. (1989). Diethylstilbestrol exposure and testicular cancer. International Journal of Epidemiology 18 (2): 462.

Finegan, J.A., B. Bartleman, and P.Y. Wong. (1989). A window for the study of prenatal sex hormone influences on postnatal development. Journal of Genetic Psychology 150: 101.
 
1990's
Reinisch, J. M., Ziemba-Davis, M., and S.A. Sanders (1991). Hormonal contributions to sexually dimorphic behavioral development in humans. Psychoneuroendocrinology, 16, 213-278.

Brahams, B. (1991). Diethylstilbestrol: Third generation injury claims. Lancet 337: 785.

Marselos, M., and I. Tomatis. (1992). Diethylstilbestrol: I, Pharmacology, toxicology, and carcinogenesis in humans. European Journal of Cancer 28A: 1182.

Reinisch, J., and S.A. Sanders. (1992). Effects of prenatal exposure to diethylstilbestrol (DES) on hemispheric laterality and spatial ability in human males. Hormones and Behavior 26 (1): 62.

Colborn, T., F.S. vonSaal, and A.M. Soto. (1993). Developmental effects of endocrine-disrupting chemicals in wildlife and humans. Environmental Health Perspectives 101: 378.

Pillard, R.C., L.R. Rosen, H.F.L. Meyer-Bahlburg, J.D. Weinrich, J.F. Feldman, R. Gruen, and A. Ehrhardt. (1993). Psychopathology and social functioning in men prenatally exposed to diethylstilbestrol (DES). Psychosomatic Medicine 55: 485.

Sharpe, R.M., and , N.E. Skakkebaek. (1993). Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet (May 29) 341: 1392.

Berendes, H.W., and Y.J. Lee. (1993). Suspended judgment: The 1953 clinical trial of diethylstilbestrol during pregnancy: Could it have stopped DES use? Controlled Clinical Trials 14: 179.

Collaer, M.L., and M. Hines. (1995). Human behavioral sex differences: A role for gonadal hormones during early development?  Psychological Bulletin (July) 118 (1): 55.

Meyer-Bahlburg, H. F. L., Erhardt, A. A., Rosen, L., Gruen, R., Veridiano, V. F. H., & Neuwalder, H. F. (1995). Prenatal estrogens and the development of homosexual orientation. Developmental Psychology, 31, 12-21.

Jones, L.A., and R.A. Hajek. (1995). Effects of estrogenic chemicals on development. Environmental Health Perspectives (October) 103 (Suppl. 7): 63.

Wilcox, A.J., D.D. Baird, C.R. Weinberg, P.P. Hornsby, and A.L. Herbst. (1995). Fertility in men exposed prenatally to diethylstilbestrol. New England Journal of Medicine (May 25) 332 (21): 1411.

Giusti, R.M., K. Iwamoto, and E.E. Hatch. (1995). Diethylstilbestrol revisited: A review of the long-term health effects. Annals of Internal Medicine (May 15) 122 (10): 778.

Dictionary of Organic Compounds, 6th Edition (1996). Buckingham, J., and F. Macdonald. (eds.): Diethylstilbestrol entry (Volume 3, 2175).

Baird, D.D., Wilcox, A.J., and Herbst, A.L. (1996). Self-reported allergy, infection, and autoimmune diseases among men and women exposed in utero to diethylstilbestrol. Journal of Clinical Epidemiology 49 (2); 263.

Laitman, C., M. Jonler, and E.M. Messing. (1997). The effects on men of prenatal exposure to diethylstilbestrol. In L.I. Lipschultz & S.S. Howards (eds.), Infertility in the male—3rd edition (St. Louis: Mosby), 268.

Kitahara, S.,  K. Yoshida, K. Ishizaki, Y. Kageyama, S. Kawakami, T.Tsujii, and H. Oshima. Stronger suppression of serum testosterone and FSH levels by a synthetic estrogen than by castration or an LH-RH agonist. Endocrine Journal (August) 44 (4): 527.

Toppari, J., and N.E. Skakkebaek. (1998). Sexual differentiation and environmental endocrine disrupters. Bailliere’s Clinical Endocrinology and Metabolism (April) 12 (1): 143.

Barlow, S., R.J. Kavlok, J.A. Moore, S.L. Schantz, D.M. Sheehan, D.L. Shuey, and J.M. Lary. (1999). Teratology Society Public Affairs Committee Position Paper: Developmental toxicity of endocrine disruptors to humans. Teratology 60: 365.
 
2000's
Gupta, C. (2000). Reproductive malformation of the male offspring following maternal exposure to estrogenic chemicals. Experimental Biology and Medicine 224: 61.

Swan, S.H. (2000). Intrauterine exposure to diethylstilbestrol: long-term effects in humans. APMIS  (December) 108 (12): 793.

Verdoux, H. (2000). Does prenatal exposure to diethylstilbestrol (DES) have psychiatric consequences? Annales Medico-Psychologiques 158 (2): 105.

Solomon, G.M., and T. Schettler. (2000). Environment and health: 6. Endocrine disruption and potential human health implications. Canadian Medical Association Journal (November 28) 163: 11.

Nef, S., T Shipman, and LF Parada. (2000). A molecular basis for estrogen-induced cryptorchidism. Developmental Biology (August 15) 224 (2): 354.

Weir, H.K., L.D. Marrett, N. Kreiger, G.A. Darlington and L. Sugar. (2000). Pre-natal and peri-natal exposures and risk of testicular germ cell cancers. International Journal of Cancer 87:438.

McLachlan, J.A., R.R. Newbold, M.E. Burow, and S. Li. (2001). From malformations to molecular mechanisms in the male: three decades of research on endocrine disrupters.  APMIS 109 (4): 263.

Strohsnitter, W.C., K.L. Noller, R.N.Hoover, S.J. Robboy, J.R. Palmer, L. Titus-Ernstoff, R.H. Kaufman, E. Adam, A.L. Herbst, and E.E. Hatch. (2001). Cancer risk in men exposed in utero to diethylstilbestrol. Journal of the National Cancer Institute (April 4), 93 (7): 545.

McLachlan, J. (2001). Environmental signaling: What embryos and evolution teach us about endocrine disrupting chemicals. Endocrine Reviews 22 (3): 319.

Sharpe, R. M. (2001). Hormones and testis development and the possible adverse effects of environmental chemicals. Toxicology Letters 120: 221.

Skakkebaek, N., Meyts, E. R., & Main, K. M. (2001). Testicular dysgenesis syndrome: An increasingly common developmental disorder with environmental aspects. Human Reproduction, 5, 972-978.

Harrison, P. (2001). Endocrine disruptors and human health: Current research will establish baseline indices. British Medical Journal (December 8) 323: 1317.

Michel, A., Mormont, C., and J.J. Legros. (2001). A psycho-endocrinological overview of transsexualism. European Journal of Endocrinology 145: 365.

Verdoux, H. (2002). Long-term psychiatric and behavioural consequences of prenatal exposure to psychoactive drugs. Therapie (March) 57(2): 181.

Damgaard, I.N., K.M. Main, J. Toppari, and N.E. Skakkebaek. (2002). Impact of exposure to endocrine disrupters in utero and in childhood on adult reproduction. Best Practice & Research Clinical Endocrinology and Metabolism 16 (2): 289.

Klip, H., Verloop, J., M.E.T.A. Koster, C.W. Burger, and F.E. van Leeuwen. (2002). Hypospadias in sons of women exposed to diethylstilbestrol in utero: A cohort study. Lancet (March 30) 359: 1102.

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